Diagnosis of Endometrial Biopsies and Curettings by Michael Mazur, , available at Book Depository with free delivery. Diagnosis of Endometrial Biopsies and Curettings: A Practical Approach. Veli Marjoniemi. x. Veli Marjoniemi. Search for articles by this author. Department of. Generally, this should comprise a formal curetting rather than an outpatient biopsy. An external Diagnostic algorithm for examination of endometrial biopsies.

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Chapman and Hall, — Sign in via your Institution Sign in. In complex hyperplasia, there is an increase in the gland to stroma ratio with diagnossis crowding. A major proportion of the workload in many histopathology laboratories is accounted for by endometrial biopsies, either curettage specimens or outpatient biopsy specimens.

J Natl Cancer Inst bipsies — The increasing use of pipelle and other methods of biopsy not necessitating general anaesthesia has resulted in greater numbers of specimens with scant tissue, resulting in problems in assessing adequacy and in interpreting artefactual changes, some of which appear more common with outpatient biopsies.

After assessing tissue that is not derived from the endometrium, the endometrial tissue present if any should be examined. Am J Surg Pathol 19 — Effects of hormones on the endometrium Hormones have varying effects on the endometrium and it is essential that the clinician supplies details to the pathologist regarding any hormone treatment.

My approach to the interpretation of endometrial biopsies and curettings

The endometrium shows proliferative activity, with bipsies dilated glands of irregular sizes and shapes. Uterine carcinosarcomas malignant mixed Mullerian tumors are metaplastic carcinomas. EIN terminology has been extensively championed by Mutter and coworkers. In most cases, this is curative, unless the sarcomatous component is high grade or there is sarcomatous overgrowth or myometrial infiltration. Most of these show an increase in the normal gland to stroma ratio, which is a defining feature of complex endometrial hyperplasia and is present in most cases of atypical hyperplasia complex atypical hyperplasia.


The glands are lined by markedly atypical nuclei, characteristic of serous biopsis.

Diagnosis of Endometrial Biopsies and Curettings : A Practical Approach

The endometrial glands are positive but the stroma is negative. Pathology of endometrium treated with tamoxifen. In APA, however, the smooth muscle stroma is generally more cellular and disorganised than normal myometrium. Product details Format Hardback pages Dimensions x x Assessing the underlying glandular architecture is problematic.

Arch Pathol Lab Med — The glands are often endometriaal packed, although some stroma usually remains between individual glands. Polyp cancers may be endometrioid in type, but serous proliferations, serous carcinoma or its precursor lesion endometrial intraepithelial carcinoma EIChave a particular propensity to arise in or be associated with otherwise benign endometrial polyps.

My approach to the interpretation of endometrial biopsies and curettings

Gynecol Oncol 55 — Before biopsy, many women with abnormal uterine bleeding are already taking exogenous hormones, especially progestogenic compounds, to control the bleeding, and this information is not always conveyed to the pathologist.


Mod Pathol 16 — Occasional stromal plasma cells may be identified in an otherwise normal endometrium, and in these circumstances a diagnosis of endometritis should not be made. The risk of developing an endometrioid adenocarcinoma after a diagnosis of atypical hyperplasia is difficult to cruettings, as, once atypical endometrial hyperplasia is diagnosed, it is treated either hormonally or more usually surgically.

The most common endometrial lesions seen in association with tamoxifen are benign polyps, which may be single or multiple.

A critical appraisal of the value of immunohistochemistry in the diagnosis of ovarian neoplasms. Cancer 56 — Tamoxifen and the endometrium: Often, the gynaecologist is not aware of the presence of a polyp. Don’t have an account? Am J Surg Pathol 4 — Bridging between adjacent glands, resulting in a cribriform pattern, as well as the presence of luminal necrosis with polymorph infiltration, suggests an adenocarcinoma.

Mixed epithelial and mesenchymal tumours.

Simple and complex hyperplastic papillary proliferations of the endometrium: Malignant neoplasms of the uterine corpus in patients treated for breast carcinoma: Endomertial simple hyperplasia, the normal gland to stroma ratio is largely maintained, although there may be a slight increase.

If you originally registered with a username please use that to sign in. Inflammation of the endometrium. Gynecol Oncol 76 —